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When a gene change that greatly increases cancer risk runs in a family, it is often referred to as a family cancer syndrome. Other terms that you might hear include inherited cancer syndrome or genetic cancer syndrome.
It's important to understand that not every cancer that seems to run in a family is caused by a family cancer syndrome. A?bout 1 in 3 people in the United States will develop cancer during their lifetime, so it’s not uncommon to have many cancers in a family. Sometimes, cancer might be more common in certain families because family members share certain behaviors or exposures that increase cancer risk, such as smoking, or because of other factors that can run in some families, like obesity.
But cancer can sometimes be caused by an abnormal gene that is passed from generation to generation. Although these cancers are often referred to as inherited cancers, what is actually inherited is the abnormal gene that can lead to cancer, not the cancer itself. Only about 5% to 10% of all cancers are known to be strongly linked to gene defects (called mutations) inherited from a parent.
To learn about the role of genes and how mutations can lead to cancer, see Genes and Cancer.
Certain things make it more likely that cancers in a family are caused by a family cancer syndrome, such as:
When trying to determine if cancer might run in your family, first collect some information. For each case of cancer, look at:
Cancer in a close relative, like a parent or sibling (brother or sister), is more likely to be a cause for concern for you than cancer in a more distant relative. Even if the cancer in a distant relative was from a gene mutation, the chance of the abnormal gene being passed on to you is less likely than with a closer relative.
It’s also important to look at each side of the family separately. Having 2 relatives with cancer is more concerning if they are on the same side of the family. For example, it’s more concerning if both relatives are your mother's brothers (because they share some of the same genes) than if one was your father's brother and the other was your mother's brother.
The type of cancer matters, too. It is more concerning if many relatives have the same type of cancer than if they have several different kinds of cancer. Still, in some family cancer syndromes, there’s an increased risk of different types of cancer. For example, the risk of breast cancer and ovarian cancer is increased (as well as some other cancers) in families with inherited breast and ovarian cancer syndrome. Colon and endometrial cancer risk are increased in Lynch syndrome (also known as hereditary non-polyposis colorectal cancer, or HNPCC).
Likewise, more than one case of the same rare cancer is more worrisome than cases of a more common cancer. For some rare cancers, the risk of a family cancer syndrome is relatively high with even one case.
The age of the person when the cancer was diagnosed is also important. For example, colon cancer is rare in people younger than 30. Having close relatives under 30 with colon cancer could be a sign of a family cancer syndrome. On the other hand, prostate cancer is very common in elderly men, so if both your father and his brother were found to have prostate cancer when they were in their 80s, it is less likely to be due to an inherited cancer syndrome.
Certain kinds of benign (not cancer) tumors and medical conditions are sometimes also part of a family cancer syndrome. For example, people with the multiple endocrine neoplasia, type II syndrome (MEN II) have a high risk of a certain type of thyroid cancer. They also may develop benign tumors of the parathyroid glands and can also get tumors in the adrenal glands called pheochromocytomas, which are usually benign.
When many relatives have the same type of cancer, it’s important to note if the cancer could be related to a risk factor like smoking. For example, lung cancer is commonly caused by smoking, so having several cases of lung cancer in a family of people who all smoke is more likely to be due to smoking than to an inherited or family cancer syndrome.
People with a strong family history of cancer may want to learn more about their genes. This may help the person or other family members plan their health care for the future. Since inherited mutations affect all cells of a person’s body, they can often be found by genetic testing done on blood or saliva (spit) samples. Still, genetic testing is not helpful for everyone, so it’s important to speak with a genetic counselor first to find out if testing might be right for you. For more information, see Understanding Genetic Testing for Cancer.
The American Cancer Society medical and editorial content team
Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as editors and translators with extensive experience in medical writing.
Along with the American Cancer Society, other sources of information and support include:
National Society of Genetic Counselors (NSGC)
Telephone: 1-312-321-6834
Website:
*Inclusion on this list does not imply endorsement by the American Cancer Society.
Aedma SK, Kasi A. Li-Fraumeni Syndrome. In: StatPearls. Treasure Island (FL): StatPearls Publishing; August 9, 2021.
Berger AH and Pandolfi PP. Chapter 5: Cancer Susceptibility Syndromes. In: DeVita VT, Lawrence TS, Lawrence TS,
Rosenberg SA, eds. DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology. 11th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2019.
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MedlinePlus. National Library of Medicine (US). Multiple endocrine neoplasia (MEN) II. 2014. Accessed at www.nlm.nih.gov/medlineplus/ency/article/000399.htm on January 26, 2022.
National Cancer Institute. Genetic Testing for Inherited Cancer Susceptibility Syndromes. 2019. Accessed at
www.cancer.gov/about-cancer/causes-prevention/genetics/genetic-testing-fact-sheet on January 26, 2022.
National Cancer Institute. Physician Data Query (PDQ). Cancer Genetics Overview – Health Professional Version. 2021. Accessed at www.cancer.gov/about-cancer/causes-prevention/genetics/overview-pdq on January 26, 2022.
National Cancer Institute. Physician Data Query (PDQ). Genetics of Breast and Gynecologic Cancers – Health Professional Version. 2021. Accessed at www.cancer.gov/types/breast/hp/breast-ovarian-genetics-pdq on January 26, 2022.
National Cancer Institute. Physician Data Query (PDQ). Genetics of Colorectal Cancer – Health Professional Version. 2021. Accessed at www.cancer.gov/types/colorectal/hp/colorectal-genetics-pdq#_72 on January 26, 2022.
Rahner N, Steinke V. Hereditary cancer syndromes. Dtsch Arztebl Int. 2008;105(41):706-714. doi:10.3238/arztebl.2008.0706.
Walsh MF, Cadoo K, Salo-Mullen EE, Dubard-Gault M, Stadler ZK, and Offit K. Chapter 13: Genetic Factors: Hereditary Cancer Predisposition Syndromes. In: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE, eds. Abeloff’s Clinical Oncology. 6th ed. Philadelphia, Pa: Elsevier; 2020.
Last Revised: September 14, 2022
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